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Used in the production of many types of plastic products, polyvinyl chloride induces angiosarcoma in exposed workers after as few as 3 years of exposure. For example, a theophylline gel (17 mg spread over an area of 2 cm in diameter) applied to the a

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In a phase I pharmacodynamic trial in solid tumor patients, plasma trough concentrations of everolimus were correlated with inhibition of mTOR as evidenced by decreased concentrations of downstream mTOR pathway proteins. When drugs are administered e

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One of the dangers of learning to work with patients and families from different cultures is confusing stereotypes with generalizations. As the number of nephrons is reduced from the initial complement of 2 million, those that are unaffected compensa

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A thorough review of the older adult's medication profile must be repeated routinely and when a care transition (ie, moving from one level of care to another) is made. Lack of controlled prospective studies makes it difficult to determine the appropr

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A set of SNPs that are inherited together is called a haplotype. The exact pathphysiologic mechanism underlying the causal relationship between hypertension to RCC is yet to be conclusively identified, but it is believed to be related to hypertension

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Directions, therapy duration, and medication cost are other issues to consider during drug regimen review that could influence adherence and lead to subsequent drug-related problems, namely ADRs and potential therapeutic failures (Table e7-7). It tak

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